For oral use

Full Spectrum Phytocannabinoids Formulations

GrowLab Pharmaceuticals’ phytocannabinoids formulations contain the two main active pharmaceutical ingredients: Cannabidiol (CBD) and Tetrahydrocannabinol (THC), as well as all other medicinal compounds of the cannabis plant such as Terpenes.





For the best possible therapy for your patients

GROWLAB GROLATINE®


CANNABINOIDS FROM GROLATINE®

Grolatine® is Hybrid Cannabis, a genetically modified breed of cannabinoid extracts from a local plant “Gilato” thus genetically named Grolatine®. It is a high quality and modified breed of cannabis leaves grown locally thus native name Gilato. Grolatine® is cultivated, grown and monitored in a specialized environment under specific weather and conditions (temperature, pressure and humidity).
The plant grows like a flower and has both leaves and flower which when matured, is deflowered, dried, and cured before the final storage in a specific glass jar for 30 days. This storage method gives room for better quality extract during the final process of producing the cannabinoid oil.

Grolatine® is rich in both CBD Oil and THC. The THC is good for recreational usage and gives high quality and loud highness as well as stable mood.
The Cannabinoid for this strain has no characteristics of highness, thus making it very good for pharmacological purposes.
The research carried out in University and University Teaching Hospital shows the pharmaco-medical importance of Cannabinoid oil grolatine in treatment of pain crisis for sickle cell disease.
Molecular structure of Cannaabinoil from Grolatine® which is employed in treatment of pain crisis in sickle cell disease patient is shown.


CANNABINOID OF GROLATINE® IN TREATMENT OF SICKLE CELL PAIN

Sickle Cell Anemia and Grolatine® Cannabinoid Oil: Effects on Pain & the Immune System


Sickle cell anemia is caused by a genetical mutation in red blood cells where amino acids valine replaces glutamine in position 6 of β chain of haemoglobin that causes them to become misshapen and unable to carry oxygen through the body.

One hundred thousand Africans are estimated to be suffering from sickle cell anemia, or sickle cell disease. As an inherited disease, this condition occurs when a child receives the trait from both parents.


At present, there are two known cures for the illness: stem cell transplant or bone marrow transplant. While these treatments are known to work, there are side effects and risks associated with them, including death. Fortunately, Cannabinoil oil may reduce the need for these procedures by making the symptoms of sickle cell anemia more manageable.

Sickle Cell Pain

Sickle cell is a genetically inherited disorder whereby valine replaces glutamine in position 6 of Beta chain of Amino acid chain of Hemoglobin.


This abnormal replacement of amino acid valine instead of glutamine makes the hemoglobin to change its shape.

The hemoglobin is the carrier that transports Red blood cells in the body normally. When the shape becomes distorted the Red blood cell will change its shape from normal spherical to abnormal sickling shape.


This abnormal sickle shape makes it difficult for blood to pass freely in the vessels.

Arteries ——> arterioles ——> capillaries ——> venule ——> vein

The difficulty in the movement of these abnormal sickle shape of red blood cells will make the blood to start accumulating in a particular place in the microvasculature. The pressures trying to move the sickling blood cells lead to pain and tissue ischemic reaction at the particular part of the body which is known as sickle cell pain crisis.

The intensity of the pain ranges from a mild pain to a moderate pain up to a severe pain. Sometimes the pain could be more severe that most opioid analgesic cannot abate it.

HOW DO CBD OIL OF GROLATINE® WORK

Mechanism of action of grolatine® CBD oil.

Cannabioil oil of Grolatine® at low dose 0.5mls causes smooth muscle relaxation and generalized vasodilation.
These actions of generalized vasodilation and smooth muscle relaxation; widening the vessels allowing blood to flow freely inside the vessels. Both the normal and abnormal shaped ones will move freely into the vessels, thus no room for aggregation of the abnormal sickled red blood cells in a particular vessel that can cause pain, and the patient will move freely and happily.

There are many clinical trials underway to assess the effect of CBD for various medical conditions, such as Randomized Controlled Trials (RCTs) investigating CBD. These (RCTs) investigating the effect of CBD oil has not been completed because the Agency (National Agency for Food and Drugs Administration NAFDAC) is yet to officially approve it, even though sickle cell disease (SCD) is seeking symptom relief with Cannabioil oil.

It is only these two conditions the RCTs investigating the effect of CBD have been completed.

1. Cannabioil oil for acute Vasoclusive crisis in sickle cell (pain crisis).
2. Cannabioil oil for reduction of bone inflammation and infection in sickle cell anemia (pain crisis).

Cannabioil oil from Grolatine® has a good safety profile and has low risk of side effect and also can interact with some common medications. So it is surely and certified as the safest option for treatment of sickle cell pain crisis.

There are different ways to use Cannabioil oil, but for our research, it is been used as a drop; and this drop will provide a consistent dose every time, and it works as a daily wellness regimen of 0.5mls per drop.

Pharmacological of Grolatine®

Grolatine® is a genetically modified breed of cannabinoid extracts from local Gillato and genetic name Grolatone. Grolatine® is a high quality and modified breed of marijuana leaves grown locally in Nigeria (Eniola Farms); thus native name Gilato. Grolatine® is cultivated, grown and monitored in a specialized environment under specific weather and condition (temperature, pressure and humidity).

Grolatine® is rich in both CBD Oil and THC. The THC is good for smoking and gives high quality highness as well as stable mood. The oil CBD has no characteristic highness, thus making it very good for pharmacological purposes. The research carried out in University of Nigeria Nsukka (UNN) and University of Nigeria Teaching Hospital (UNTH) shows the pharmaco-medical importance of CBD Oil Grolatine® in treatment of pain crisis in a patient with sickle cell disease.

CBD Oil from Grolatine® has a good safety profile and has low risk of side effect and it can interact with some common medications. So it is surely and certified as the safest option for treatment of both sickle cell pain crisis and early stage of cancer of prostate. There are different ways to use CBD Oil but for our research it is been used as a drop and nanomodified liquid as a daily wellness regimen of 0.5mls per drop and we hope to come out with a better result. Apart from the treatment of sickle cell pain crisis and other related sickle cell complications such as reduced frequency of recurrent bone inflammation and infection, another great pharmacological and biomedical breakthrough of the use of CBD Oil from Grolatine® has been discovered.

Nanomodified CBD Oil of Grolatine® has been found to be effective in treatment of cancer of the prostate. It is more effective and better result oriented when the cancer is diagnosed earlier.

Prostate:
Prostate is a small gland that is normally attached to the male Urether immediately below the neck of the bladder. It is found to increase with age and its enlargement starts at an average age of 45 years and above. sometimes or most times the enlargement will be much that it can lead to urinary obstruction, and the patient will find it difficult to urinate freely. The enlarged prostate gland could be as a result of cancer (Malignant Prostatic Hypertrophy) or non cancerous (Benign Prostatic Hypertrophy (BPH). Which ever way, Grolatine® has been found to be effective in treatment of both conditions.


More findings:
This special and modified process of preparing this CBD Oil (Grolatine®) made it possible for it to be soluble in both water and fats and can easily be absorbed through the gastrointestinal tract. From our studies so far with most of our patients under trials, Grolatine® reduces the size of the enlarged cancerous prostate gland, and equally reduces pain associated with the cancer.

Patients celebrate the effectiveness of its pain reliever (analgesic property) that it can be scored above 70%; compared to opoid and codeine which their effectiveness in pain reduction is below 60%. It’s elastic pain duration is rated 10 to 12 hours unlike opoid and codeine whose duration range between 6 – 8 hours. As a result of this, it is easy to take; instead of 6 hourly (3 times) daily for other analgesic it is taken 12 hourly (2 times daily) making compliance very easy. Again unlike opoid it has minimal side effect; as non of the patients has complained of vomiting, weakness or highness; and it has very minimal or no addictive properties.

The effect of Grolatine® on the Prostate gland
It has been found from those on clinical trials that Grolatine® reduces the size of prostate gland, as it is been monitored using serial ultrasound scan follow up and quick relief of the symptoms associated with enlarged gland such as early difficulty in micturition and reduced suprapubic discomfort.

Good enough, this particular effect is very important because it benefits both patient that have Benigh Prostatic Hypertrophy (BPH) which is not cancerous and those suffering from malignant Prostate Hypertrophy (MPH). Continous monitoring and testing of blood sample of those patients that atre taking Grolatine® has shown that it reduces the level of the tumor maker associated with Prostate Cancer and Benign prostate hypertrophy i.e. Prostate Surface Antigen(PSA).

The full mechanism of action of Grolatine® on the pain associated with Prostate
Cancer and reduction in size of the tumor are not fully known, as the studies and research are still on going in our institution. though we hope to reach there with time.

HIGHEST QUALITY

Thanks to controlled tests and high-quality production systems, we can always guarantee the consistently high pharmaceutical quality of our extract


MADE IN AFRICA

Our full spectrum phytocannabinoids therapies are synthesised exclusively in European Medicines Agency cGMP compliant production facilities.


PRECISE AND EASY DOSING

Dosing pipettes make it easy and precise to use.


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